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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: S1PR1 All Species: 27.27
Human Site: S359 Identified Species: 60
UniProt: P21453 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21453 NP_001391.2 382 42811 S359 R S K S D N S S H P Q K D E G
Chimpanzee Pan troglodytes XP_513598 382 42768 S359 R S K S D N S S H P Q K D D G
Rhesus Macaque Macaca mulatta XP_001107778 331 36908 H309 S K S D N S S H P Q K D D G D
Dog Lupus familis XP_547259 382 42503 S359 R S K S D N S S H P Q K D D G
Cat Felis silvestris
Mouse Mus musculus O08530 382 42595 S359 R S K S D N S S H P Q K D D G
Rat Rattus norvegicus P48303 383 42727 S360 R S K S D N S S H P Q K D D G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520197 378 41947 S355 R S K S D N S S H P Q K D E G
Chicken Gallus gallus XP_422305 379 42371 S356 R S K S D N S S H P Q K E E G
Frog Xenopus laevis Q9PU17 366 41345 D344 N G P T E G S D R S A S S L N
Zebra Danio Brachydanio rerio Q9DDK4 362 40583 N340 S D N S S H P N K D E P E Y S
Tiger Blowfish Takifugu rubipres Q9PUQ8 384 42694 L351 Q S S R P A E L D R E Q E T G
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 85 95 N.A. 93.9 93.2 N.A. 85.8 84.2 36.6 68 48.9 N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 85.5 97.6 N.A. 96.8 96.3 N.A. 89.5 90.3 59.6 80.3 69.7 N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 13.3 93.3 N.A. 93.3 93.3 N.A. 100 93.3 6.6 6.6 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 33.3 100 N.A. 100 100 N.A. 100 100 20 33.3 40 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 10 64 0 0 10 10 10 0 10 64 37 10 % D
% Glu: 0 0 0 0 10 0 10 0 0 0 19 0 28 28 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 0 10 0 0 0 0 0 0 0 10 73 % G
% His: 0 0 0 0 0 10 0 10 64 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 64 0 0 0 0 0 10 0 10 64 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 10 64 0 10 0 0 0 0 0 0 10 % N
% Pro: 0 0 10 0 10 0 10 0 10 64 0 10 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 10 64 10 0 0 0 % Q
% Arg: 64 0 0 10 0 0 0 0 10 10 0 0 0 0 0 % R
% Ser: 19 73 19 73 10 10 82 64 0 10 0 10 10 0 10 % S
% Thr: 0 0 0 10 0 0 0 0 0 0 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _